H2N2V1, Main, Exploration, bibRecord, 001D47

Nucleotide sequences of the neuraminidase genes of influenza A/Leningrad/134/57 (H2N2) virus and two of its live, attenuated, cold-adapted variants

Identifieur interne : 001D47 ( Main/Exploration ); précédent : 001D46; suivant : 001D48

Nucleotide sequences of the neuraminidase genes of influenza A/Leningrad/134/57 (H2N2) virus and two of its live, attenuated, cold-adapted variants

Auteurs : Alexander I. Klimov [États-Unis, Russie] ; Julia R. Romanova [Russie] ; Andrei Y. Egorov [Russie] ; Irina V. Lukashok [Russie] ; Irina V. Kiseleva [Russie] ; Galina I. Alexandrova [Russie] ; Nancy J. Cox [États-Unis]

Source :

Virus Genes [ 0920-8569 ] ; 1995-02-01.

RBID : ISTEX:0BEAE642F66B48F8E586BEA20799C8E874A13D0A

Descripteurs français

KwdFr :
- ADN viral, Données de séquences moléculaires, Humains, Sialidase (génétique), Sous-type H2N2 du virus de la grippe A, Séquence d'acides aminés, Séquence nucléotidique, Variation génétique, Virus de la grippe A (enzymologie), Virus de la grippe A (génétique), Virus recombinants (génétique).
MESH :
- enzymologie : Virus de la grippe A.
- génétique : Sialidase, Virus de la grippe A, Virus recombinants.
- ADN viral, Données de séquences moléculaires, Humains, Sous-type H2N2 du virus de la grippe A, Séquence d'acides aminés, Séquence nucléotidique, Variation génétique.

English descriptors

KwdEn :
- Amino Acid Sequence, Base Sequence, DNA, Viral, Genetic Variation, Humans, Influenza A Virus, H2N2 Subtype, Influenza A virus (enzymology), Influenza A virus (genetics), Molecular Sequence Data, NA gene, Neuraminidase (genetics), PCR restriction analysis, Reassortant Viruses (genetics), influenza A virus, nucleotide sequence.
MESH :
- chemical , genetics : Neuraminidase.
- enzymology : Influenza A virus.
- genetics : Influenza A virus, Reassortant Viruses.
Teeft :
- Alexandrova, Amino Acid Sequence, Attenuated, Base Sequence, Bgli, Bgli restriction site, Coding mutation, DNA, Viral, Disease control, Gene, Genetic Variation, Genome, Humans, Influenza, Influenza A Virus, H2N2 Subtype, Influenza branch, Kendal, Klimov, Master strains, Medical sciences, Molecular Sequence Data, National center, Nucleotide, Nucleotide change, Nucleotide differences, Nucleotide sequence, Nucleotide sequences, Reassortant, Reassortants, Restriction analysis, Rickettsial diseases, Russian academy, Sequence data, Vaccine.

Abstract

Abstract: The nucleotide sequences of the neuraminidase (NA) genes of the A/Leningrad/134/57 (H2N2) wild-type (Len/wt) virus as well as two of its live attenuated, cold-adapted (ca) variants, A/Leningrad/134/17/57 (Len/17) and A/Leningrad/134/47/57 (Len/47), were determined. In comparison with Len/wt, one nucleotide change (C-225 to A) was found in the NA gene of Len/17. This change codes for a Thr-to-Asn substitution at position 69 of NA. The NA gene of the more attenuated Len/47 ca virus has one silent (T-814 to C) and two coding nucleotide substitutions, C-78 to T (Ala-20 to Val) and C-225 to A (Thr-69 to Asn). These sequence data were used to design a PCR-restriction technique to determine the origin of the NA gene in candidate live, attenuated vaccine reassortants made by reassorting these ca strains with current field viruses.

Url:

https://api.istex.fr/ark:/67375/1BB-Q20DJBT2-5/fulltext.pdf

DOI: 10.1007/BF01724302

Affiliations:

Le document en format XML

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<term>Genetic Variation</term>
<term>Humans</term>
<term>Influenza A Virus, H2N2 Subtype</term>
<term>Influenza A virus (enzymology)</term>
<term>Influenza A virus (genetics)</term>
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<term>Neuraminidase (genetics)</term>
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<term>influenza A virus</term>
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<term>Sialidase (génétique)</term>
<term>Sous-type H2N2 du virus de la grippe A</term>
<term>Séquence d'acides aminés</term>
<term>Séquence nucléotidique</term>
<term>Variation génétique</term>
<term>Virus de la grippe A (enzymologie)</term>
<term>Virus de la grippe A (génétique)</term>
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<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Influenza A virus</term>
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<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A virus</term>
<term>Reassortant Viruses</term>
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<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Sialidase</term>
<term>Virus de la grippe A</term>
<term>Virus recombinants</term>
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<term>Base Sequence</term>
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<term>Bgli restriction site</term>
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<term>Genetic Variation</term>
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<front><div type="abstract" xml:lang="en">Abstract: The nucleotide sequences of the neuraminidase (NA) genes of the A/Leningrad/134/57 (H2N2) wild-type (Len/wt) virus as well as two of its live attenuated, cold-adapted (ca) variants, A/Leningrad/134/17/57 (Len/17) and A/Leningrad/134/47/57 (Len/47), were determined. In comparison with Len/wt, one nucleotide change (C-225 to A) was found in the NA gene of Len/17. This change codes for a Thr-to-Asn substitution at position 69 of NA. The NA gene of the more attenuated Len/47 ca virus has one silent (T-814 to C) and two coding nucleotide substitutions, C-78 to T (Ala-20 to Val) and C-225 to A (Thr-69 to Asn). These sequence data were used to design a PCR-restriction technique to determine the origin of the NA gene in candidate live, attenuated vaccine reassortants made by reassorting these ca strains with current field viruses.</div>
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Serveur d'exploration H2N2

Nucleotide sequences of the neuraminidase genes of influenza A/Leningrad/134/57 (H2N2) virus and two of its live, attenuated, cold-adapted variants

Nucleotide sequences of the neuraminidase genes of influenza A/Leningrad/134/57 (H2N2) virus and two of its live, attenuated, cold-adapted variants

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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